Low-density polyethylene (LDPE) is commonly used as food packaging material because of its affordability, convenience and versatility. However, there are concerns regarding the chemical migration of contaminants into food especially at high temperatures, and thus requires further investigation. The study documented the total residual contaminants (TRCs) that migrate into fatty and oily foods from LDPE food contact articles (FCAs) that are sold in the Philippines to fill a major gap in the country’s regulatory system. The study compared two international standard methods 21 Code of Federal Regulations (CFR) Part 177 and Japan External Trade Organization (JETRO 2009)—to assess their suitability for local applications. The researchers collected and analysed 23 LDPE samples across Mega Manila to estimate residue concentrations. Results indicate that TRC levels of FCAs exhibited statistically significant differences among the collection sites which may be influenced by factors such as environmental exposure, transportation and handling. Samples with the lowest and highest TRC concentrations from the 23 LDPE samples were selected for the comparative studies of the two international methods. Each low- and high-level sample underwent analysis using the testing conditions of both methods. A comparative analysis using paired t-test revealed distinct variations between the methods, with US 21 CFR giving higher concentrations at low-level samples (9.34 mg/L TRCs), and JETRO 2009 at high-level samples (19.6 mg/L TRCs). Statistical validation confirmed these differences, highlighting the need for rigorous method validation and harmonization of international and local testing standards. These findings also highlight the significance of the development of regulatory frameworks and robust testing methods that are specific to the Philippines’ environmental and industrial conditions in order to ensure food safety and enhance the country’s global competitiveness.